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KMID : 1011920200210010010
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International Journal of Arrhythmia
2020 Volume.21 No. 1 p.10 ~ p.10
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Prognostic value of routine blood tests along with clinical risk factors in predicting ischemic stroke in non-valvular atrial fibrillation: a prospective cohort study
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Yang Seok-Hun
Cha Myung-Jin
Kwak Soon-Gu
Kwon Soon-Il
Lee Seo-Young
Park Jie-Suck
Choi You-Jung
Moon In-Ki
Lee Eui-Jae
Lee So-Ryoung
Choi Eue-Keun
Oh Se-Il
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Abstract
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Background: In patients with atrial fibrillation (AF), most biomarkers are still of limited use due to cost-effectiveness and complexity in clinical practice.
Hypotheses: Biomarkers from routine blood tests improve the current risk stratification in AF patients.
Methods: This prospective study enrolled 600 patients diagnosed with non-valvular AF, of whom 537 were analyzed. Platelet count; platelet distribution width (PDW); red cell distribution width (RDW); and creatinine, D-dimer, and troponin I levels were measured at enrollment.
Results: During the mean follow-up period (2.2?±?0.6 years), 1.9% patients developed ischemic stroke. According to the optimal cutoff of each biomarker, the risk of ischemic stroke was higher in patients with RDW?≥?13.5%, creatinine?≥?1.11 mg/dL, or PDW?≥?13.2% (significant biomarkers; P value:?
Conclusion: Routine blood tests can provide better risk stratification of AF along with clinical risk factors.
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KEYWORD
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Atrial fibrillation, Biomarkers, Stroke, Thromboembolism
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